Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

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Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-pot three- component condensation of aldehydes, amines, and potassium cyanide in acetonitrile in the presence of a catalytic amount of CoCl2 at room temperature.

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The reaction of 2-naphthol and also para-substituted phenols with glyoxal in presence of choline chloride: 2 ZnCl2 [ChCl: 2ZnCl2], a deep eutectic solvent (DES), as a green catalyst was studied. The amount of catalyst, solvent type, temperature, and time on the yield of reaction were investigated. It was found that the optimal condition included 10% mol ratio of catalyst (mol percentage of DES ...

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Mesolite catalyzed one pot synthesis of quinoline-3-carbonitrile derivatives

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Mesolite catalyzed one pot synthesis of quinoline-3-carbonitrile derivatives

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2005

ISSN: 1860-5397

DOI: 10.1186/1860-5397-1-8